Navegação Eventos - Resumos por Autores IPEN "VARCA, G.H."

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  • IPEN-DOC 27640

    LIMA, C.S. ; VARCA, G.H. ; OLIVEIRA, J.R. ; NOGUEIRA, K.M. ; SANTOS, F.A. ; RIBEIRO, A.H. ; LUGAO, A.B. ; FREITAS, L.F. ; ROGERO, S.O. . CMC and PVA hydrogel containing papain nanoparticles for drug delivery. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Four hydrogel formulations of Carboxymethylcellulose (CMC) and Poly (vinyl alcohol) (PVA) were prepared with native papain (AP and BP) and papain nanoparticles (AN and BN) for drug delivery. The formulations were evaluated for their preliminary stability, protein distribution in the matrix and cytotoxicity. Three methods for sterilization purposes were compared: irradiation by 60Co source, electron-beam and UV light. The preliminary stability test confirmed that the system was stable since there was no precipitation or alteration of the organoleptic properties of the samples in the evaluated period. The distribution of proteins in the hydrogel was very homogeneous in all the formulations. Quantification of the enzymatic activity of papain after contact with the gel showed that native papain maintained its activity high (86% and 93% for AP and BP gels, respectively), whereas there was a considerable drop in the activity of the papain nanoparticles to 60.54% and 69.44% for AP and BP gels, respectively. Such loss of activity is attributed to processing and/or process steps. The cell viability assay showed that the polymer matrix shows no cytotoxicity, corroborating with the literature, since the material is biocompatible. Thus, it is possible to affirm that the developed system presents potential for biomedical application, either as a vehicle of papain itself or for the transport of other drugs through complexation with papain nanoparticles. However, the need for further studies of stability, controlled release capacity and biocompatibility is required.

  • IPEN-DOC 27642

    NOGUEIRA, K.M. ; VARCA, J.O. ; LIMA, C.S. ; CRUZ, C.C. da ; RIBEIRO, A.H. ; FREITAS, L.F. ; VARCA, G.H. ; LUGAO, A.B. . Development of Lignin/PEO nanofibers by electrospinning technique for tissue engineering application. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Lignin is a renewable carbon source and has been widely explored in different areas over the last years, especially in biomaterials such as dressings and other biomedical devices due its natural origin and low cost. Its chemical structure confers interesting properties such as antioxidant capacity, UV protection, bactericidal action and appropriate adsorption. Poly (ethylene oxide) (PEO) is used in electrospinning to facilitate the formation polymer fibers. The electrospinning technique has been largely explored in the bioengineering area towards designing nanomaterial with minimum defect and high surface area. The present work aimed the development of a lignin/PEO nanofiber by electrospinning technique. In practical terms, lignin/PEO solution was prepared following two different methods. In the first approach, polymer stock solutions were prepared in alkaline water by stirring at 70 °C. In the second, the polymer powders were mixed and dissolved together in dimethylformamide (DMF) under stirring at 80 °C. By both methods, PEO/lignin solutions were prepared at 10, 20 e 30% (w,v) solid content, at the ratios 99/1 and 95/5. For electrospinning parameters, the distance between ejector and plate collector was set to 15-20 cm, voltage to 20 kV and injection flow to 1 mL/h, chamber temperature to 40 °C and 30%. Nanofiber morphology was assessed by scanning electron microscopy and optical coherence tomography. Apparent porosity was measured by classical Archimedes method. Due to higher DMF dielectric constant compared to water, results showed that nanofibers made using DMF presented smaller beats formation and smaller fiber diameter. Nanofibers with higher solid content presented more uniform fibers with larger diameter. Nanofibers with higher lignin concentration presented larger number of beats and higher fiber diameter. However, lignin improved the system porosity in all cases. Further mechanical and biological experiments will be done, nevertheless, the nanofiber developed is a promising material to be applied in tissue engineering.

  • IPEN-DOC 27677

    FREITAS, L.F. ; CRUZ, C.C. da ; BATISTA, J.G. ; VARCA, G.H. ; LUGAO, A.B. ; MATHOR, M.B. . Hybrid gold-protein nanoparticles as radiosensitizers. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Gold nanoparticles present unique optical properties which are dependent upon size and morphology, and consist on a differential interaction with radiation compared to the bulk material. Those nanoparticles can be modified in order to adjust their bioavailability and tissue-targeting, and one of the means to do so is by adsorbing one or more types of proteins onto their surface. Gamma radiation can be helpful in this regard, since it promotes intra- and intermolecular crosslinks in proteins and enables their adsorption onto the metallic nanoparticles’ surfaces. Here we present the results obtained for hybrid gold-protein nanoparticles as radiosensitizers. The nanoparticles were synthesized radiolytically by mixing 5 mmol L-1 NaAuCl4 with 1 mg mL-1 bovine serum albumin (BSA) or papain in the presence of 0.1 mol L-1 tert-butanol and 20% ethanol. The solutions were irradiated with 10 kGy in a multipurpose gamma irradiator (60Co source, 5 kGy per hour) for the radiolytic synthesis of the nanoparticles, and then the resulting red suspension was stored until use. 10^4 cells (MDA-MB-231 line) were seeded in 96-well plates and incubated with a 2:1 mixture of DMEM medium and nanoparticles suspension for 12 hours. Then, the wells were washed with sterile phosphate buffered saline, and fresh DMEM medium was added prior to irradiation in a gamma cell (60Co source, 0.6 kGy per hour) with 10, 30 and 50 Gy. 48 hours later, the cell viability was assessed by MTS assay. The results indicate that the radiation alone slightly stimulated the proliferation of the tumor cells, but this effect was more evident in the presence of gold-papain nanoparticles. The ablative effect due to radiosensitization was observed with 30 and 50 Gy for the cells incubated with gold-BSA nanoparticles, and 10 and 30 Gy for the cells incubated with gold-papain nanoparticles. This difference might be due to a more effective internalization or surface-attachment of nanoparticles when they are coated with papain, and one evidence for this assumption is the fact that the cell culture becomes red after the incubation with gold-papain nanoparticles. Therefore, protein-coated nanoparticles might be effective as radiosensitizers, depending on the coating and dose of radiation.

  • IPEN-DOC 27654

    BALOGH, T.S. ; KADLUBOWSKI, S.; BONTURIM, E.; LUGAO, A.B. ; VARCA, G.H. . Influence of argon and nitrous oxide on the synthesis of PVP nanogels prepared by gamma radiation. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Nanogels are innovative systems with great potential for use in chemotherapy, disease diagnosis, release of bioactive substances, vaccines, cell culture systems, biocatalysis, in the generation of bioactive scaffolds in regenerative medicine among other applications. The definition of this material can be directly derived from the definition of polymeric gel, that is, a two-component system consisting of a permanent three-dimensional network of linked polymer chains and solvent molecules filling the pores of this network. Its internal structure is similar to that of hydrogels however presents particle size range varying from 0 to 100 nm leading to several advantages. Nanogel production methods involve intramolecular crosslinking that can be achieved using ionizing radiation. This method avoids the addition of any additives allowing the reaction to be carried out in a pure polymer-solvent system and the production of nanogels for biomedical applications free from monomer and crosslinking agents or surfactants. In this work influence of argon and nitrous oxide on the formation of nanogels by gamma irradiation has been evaluated. The samples were prepared in duplicate in multipurpose cobalt-60 gamma irradiator using a 25 mM PVP solution. Samples were irradiated in argon and nitrous oxide conditions with doses from 1 kGy up to 25 kGy with 10 kGy/h dose rate. These samples were morphologically characterized using Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) as well as the pristine PVP solution. The mean particle size of the samples and the polydispersity index was performed in equipment Zetasizer Nano ZS - Malvern® and the determination of radius of gyration and molecular weight was performed in equipment Heleos - Wyatt®. It was observed in the conditions evaluated that saturation with argon or nitrous oxide promoted similar results except for 25 kGy dose. At this dose larger mean particle size and radius of gyration were observed in the sample saturated with nitrous oxide.

  • IPEN-DOC 23778

    VARCA, G.H. ; MOHAMED, L.B. ; FAZOLIN, G.N. ; OLIVEIRA, J.P. ; BATISTA, J.G. ; LUGAO, A.B. . Protein crosslinking by high energy irradiation - towards the development of size-controlled biocompatible nanocarriers. In: CONGRESSO LATINO-AMERICANO DE ORGAOS ARTIFICIAIS E BIOMATERIAIS, 9; CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGAOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 13., 24-27 de agosto, 2016, Foz do Iguaçu, PR. Abstract... 2016. p. 1162-1162.

    Abstract: Protein and peptide based delivery systems are on the spotlight considering their unique properties specially related to site specific delivery and high biocompatibility despite other biopharmaceutical advantages. Following the recent success of the so-called NAB platform, most of the attention has been driven towards the development of cosolvent -free or crosslinker-free technologies capable of producing protein nanoparticles with a specific size or shape, in the seek for better or preferential tumor uptake and low or negligible toxicity among other features. Within this context irradiation stands a tool capable of promoting protein crosslinking and sterilization of the systems simultaneously, in which combined or not with other techniques may allow the design of nanocarriers without the need of monomers or toxic crosslinkers. This research details the use of high energy irradiation towards the design of size-controlled protein-based nanocarriers for drug delivery. The albumin or papain based nanocarriers were designed by combining desolvation/solvation techniques followed by gamma irradiation or gamma irradiation alone. Sizecontrolled nanocarriers were manufactured up to 80 nm, as determined by dynamic light scattering, depending upon the protein or the presence of cosolvent. Nanocarrier morphology was evaluated by transmission electron microscopy, and protein crosslinking was evaluated by means of bityrosine formation using fluorescence measurements. Final applications of the developed systems comprise relevant potential for the delivery of radiopharmaceuticals or chemotherapic agents.

  • IPEN-DOC 27635

    FERREIRA, A.H. ; MARQUES, F.N.; SOUZA, L.E. de; VARCA, G.H. ; REAL, C.C.; FARIA, D.d.; JUNQUEIRA, M.d.; LUGAO, A.B. ; FREITAS, L.F. . Radiolabeled protein nanoparticles for cancer diagnosis. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Recent advances in nanomedicine and nanotechnology have expanded the development of multifunctional nanostructures which combine specificity, diagnostic and therapeutic functions in nanostructured complexes in order to overcome biological barriers that may hinder the selective and effective administration and uptake of drugs and diagnostic agents in tumor tissue. Nanoparticles have been used in nuclear medicine as nano-radiopharmaceuticals to carry PET and SPECT ?- and ?-emitting radioisotopes used in endoradiotherapy to specifically destroy tumor tissue. The aim of the present work was the study of radiolabeling of albumin (BSA-NPs) and papain (P-NPs) nanoparticles synthesized by gamma irradiation, with 99mTc and characterize their in vitro and in vivo properties as potential novel nano-radiopharmaceuticals. Electron microscopy and light scattering techniques show spherical shapes of nanoparticles and average diameter of 9.3 ± 1.9 nm for P-NPs and 25.1 ± 2.9 nm for BSA-NPs. The radiolabeling reached around 90% yield, and the 99mTc-BSA-NPs showed stability for 24 h in all assayed conditions, while 99mTc-P-NPs presented stability for 6 h in human serum. The biodistribution studies in healthy animals have shown different excretion profiles, 99mTc-P-NPs featured a renal excretion. On the other hand the 99mTc-BSA-NPs were found in the liver and spleen to a larger extent, undergoing hepatic excretion. In vitro studies showed promising internalization rates for both nanoparticles with 74% and 57.6% of total uptake in MDA-MB231 cells, respectively for 99mTc-P-NPs and 99mTc-BSA-NPs. In vivo studies in micro-SPECT/CT images also showed a high tumor uptake for both nanoparticles. The autoradiographic studies and immunohistochemistry assays revealed a high density of both papain and BSA nanoparticles in peripheral regions of tumor tissue and confirmed the efficacy of the developed nano-radioparmaceuticals for targeting breast cancer.

  • IPEN-DOC 27639

    FREITAS, L.F. ; CRUZ, C.C. da ; BATISTA, J.G. ; VARCA, G.H. ; LUGAO, A.B. ; PIRES, M.A. . Stability of gold nanoparticles in different ionic concentrations and pH: a comparison among synthetic protocols. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: There are several protocols for the synthesis of gold nanoparticles, and lately there is a trend for green methods in order to minimize the environmental impacts. The reduction of gold salts by epigallocatechin 3 gallate, for instance, generates stable and uniform nanoparticles without the use of toxic compounds, and so does the radiolytic synthesis protocol. For medical purposes, proteins like albumin and papain are useful coating agents, providing a better biological effectiveness. Here we present a comparison of different synthetic and protein coating protocols for gold nanoparticles regarding their stability in different NaCl concentrations and pH, aiming for the development of nanoparticles that are able to be administered in physiologic solutions to patients. The nanoparticles were synthesized via EGCG (2 mg mL 1) reduction of gold salt (5 mmol L 1) in phosphate buffer pH 7.0. Those nanoparticles were coated or not with albumin or papain (1 mg mL 1) using mercaptopropionic acid. Other protein coated gold nanoparticles were synthesized radiolytically by mixing 5 mmol L 1 NaAuCl4 with 1 mg mL 1 bovine serum albumin (BSA) or papain and 0.1 mol L 1 tert butanol. The solutions were irradiated with 10 kGy (60Co source, 5 kGy h 1) and the resulting suspensions were stored until use. The suspensions were added in 96 well plates to solutions with different pH and NaCl concentrations, and their absorption spectra were taken periodically to verify their stability. It was observed that BSA gold nanoparticles synthesized by both protocols were stable in concentrations of NaCl varying from 0.1% to 14.4% up to 72h. The papain gold nanoparticles synthesized by both protocols were stable in concentrations of NaCl varying from 0.1% to 14.4% up to 48h, but in 72h there was evidence of instability in the lowest and highest NaCl concentrations. The nanoparticles coated just with EGCG (without proteins) were stable in all NaCl concentrations and times, except in the highest concentration after 72h. Regarding the pH, BSA gold nanoparticles and papain gold nanoparticles synthesized radiolytically, as well as EGCG gold nanoparticles were stable at least in pH varying from 5 to 11, in all times analyzed. In conclusion, all the nanoparticles tested are able to be administered to patients in physiological solutions, which have pH around 7.4 and NaCl concentrations around 0.9%, without the risk of aggregation and loss of biological activity.

  • IPEN-DOC 27644

    RIELLO, F.N. ; VARCA, G.H. ; LIMA, C.S. ; FREITAS, L.F. ; FERREIRA, A.H. ; LUGAO, A.B. . Synthesis and purification of albumin-based nanoparticles crosslinked by radiation. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. Abstract... 2020.

    Abstract: Protein-based nanoparticles have been proved a promissing alternative for the loading and delivery of chemotherapeutic agents, radiopharmaceutics and other drugs of interests, constituting a less toxic therapeutic option due to its biocompatibility and low or null side effects. The use of radiation to crosslink or form covalent bonds enables the controll of the crosslinking process, without the need for crosslinking agents, as well as provides sterilizations simultaneously, withouth generating toxic compounds or products. The present work targets the synthesis an purification of albumin-based nanocarrier crosslinked by gamma radiation for biomedical applications. For such purpose, albumin nanoparticles were synthesized using BSA at 20% ethanol (v/v) in 50 mM phosphate buffer on an ice bath prior to and after irradiation. Samples were exposed to gamma radiation at a minimun absrobed dose of 10 kGy at 5kGy.h-1 and purified using a SuperdexTM 200 Increase 10/300GL for isolating the crosslinked protein (high molecular weight) from the native BSA. After the purification, the fractions were characterized by electrophoresis, Uv, fluorescence and dynamic light scaterring. The nanoparticles were obtained in the range of 25-40 nm and purified into fractions of high molecular weight and the native ones. The high molecular weight fractions presented increased bityrosine levels if compared to the fraction corresponded to the native BSA. The yields of nanoparticle formation remains to be determined, but our results provided a clear evidence of the formation of radiation-crosslinked BSA nanoparticles and the role of bityrosine in the nanoparticle assembly.

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A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.