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IPEN-DOC 24763
- NASCIMENTO, M.H.M.
;- FRANCO, M.K.K.D.
; - YOKAICHYIA, F.
;- PAULA, E. de
;- LOMBELLO, C.B.
;- ARAUJO, D.R. de
. Hyaluronic acid in Pluronic F-127/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release. International Journal of Biological Macromolecules, v. 111, p. 1245-1254, 2018. DOI: 10.1016/j.ijbiomac.2018.01.064 Abstract: In this study,we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/ or Pluronic F-108 (PLF-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries.We have studied the HA-micelle interaction using Dynamic Light Scattering (DLS), themicellization and sol-gel transition processes by Differential Scanning Calorimetry (DSC) and Rheology., of PL-based hydrogels and. The presence of HA provided the formation of larger micellar dimensions from ~26.0 to 42.4 nm. The incorporation of HA did not change the micellization temperatures and stabilized hydrogels rheological properties (G′ N G″), showing no interference on PLthermoreversible properties. Small-Angle-X-ray Scattering (SAXS) patterns revealed that HA incorporation effects were pronounced for PLF-127 and PLF-108 systems, showing transitions from lamellar to hexagonal phase organization (HA-PLF-127) and structural changes from cubic to gyroid and/or cubic to lamellar. The HA insertion effects were also observed on drug release profiles, since lower LDC release constants (Krel = 0.24–0.41 mM·h−1) were observed for HA-PLF-127, that presented a hexagonal phase organization. Furthermore, the HA-PL systems presented reduced in vitro cytotoxic effects, pointed out their tendency to selfassembly and possible application as drug delivery systems.Palavras-Chave: hyaluronic acid; pluronics; hydrogels; anesthetics; calorimetry; toxicity; micellar systems; small angle scattering; drug delivery
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IPEN-DOC 16961
- ZULLI, GISLAINE
;- LOPES, PATRICIA S.
;- ALCANTARA, MARA T.S.
; - VELASCO, MARIA V.R.
;- MIYAMARU, LIGIA L.
;- BARBARA, MARIA C.S.
;- ROGERO, SIZUE O.
; - LUGAO, ADEMAR B.
;- MATHOR, MONICA B.
. In vitro and in vivo toxicology evaluation to determine suitable biomedical polymers for development of a papain-containing drug delivery system.
Latin American Journal of Pharmacy,
v. 30,
n. 6,
p. 1104-1108,
2011.
Palavras-Chave: papain; epidermis; cytology; toxicity; polymers; drug delivery; in vitro; in vivo
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IPEN-DOC 23189
- PRADO, ANDRESSA R.
;- YOKAICHYIA, FABIANO
;- FRANCO, MARGARETH K.K.D.
; - SILVA, CAMILA M.G. da
;- OLIVEIRA-NASCIMENTO, LAURA
;- FRANZ-MONTAN, MICHELLE
;- VOLPATO, MARIA C.
;- CABECA, LUIS F.
;- PAULA, ENEIDA de
. Complexation of oxethazaine with 2-hydroxypropyl-bcyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues. Journal of Pharmacy and Pharmacology, v. 69, n. 6, p. 652-662, 2017. DOI: 10.1111/jphp.12703 Abstract: ObjectivesOxethazaine (OXZ) is one of the few local anaesthetics that provides analgesia at low pH, but presents poor solubility, cytotoxicity and no parenteral formulations. To address these issues, we aimed to prepare OXZ host-guest inclusion complex with hydroxypropyl-beta-cyclodextrin (HP--CD). MethodsThe inclusion complex was formed by co-solubilization, followed by a job plot analysis to determine stoichiometry of complexation and dialysis equilibrium analysis (based on UV/VIS absorption and fluorescence profiles of OXZ). Complex formation was confirmed by phase-solubility data, X-ray, Scanning Electron Microscopy and DOSY-H-1-NMR experiments. In vitro cytotoxicity was analysed by MTT test in 3T3 fibroblasts. In vivo analgesia was tested by Von Frey test (inflammatory wounds - rats). Key findingsOxethazaine complexed (1 : 1 molar ratio) with HP--CD, as indicated by loss of OZX crystalline structure (X-ray) and strong host: guest interaction (NMR, K = 198/M), besides increased solubility. In vitro cell survival improved with the complex (IC50 OXZ = 28.9 m, OXZ : HP--CD = 57.8 m). In addition, the complex (0.1% OXZ) promoted in vivo analgesia for the same time that 2% lidocaine/epinephrine did. Conclusion Our results show that complexation improved physicochemical and biological properties of OXZ, allowing its application to inflamed tissues by parenteral routes.Palavras-Chave: analgesics; anesthesia; bioassay; drug delivery; pharmacology; drugs; therapeutic doses
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IPEN-DOC 23168
- GALANTE, RAQUEL
;- REDIGUIERI, CAROLINA F.
;- KIKUCHI, IRENE S.
;- VASQUEZ, PABLO A.S.
; - COLACO, ROGERIO
;- SERRO, ANA P.
;- PINTO, TEREZINHA J.A.
. About the sterilization of chitosan hydrogel nanoparticles. Plos One, v. 11, n. 12, 2016. DOI: 10.1371/journal.pone.0168862 Abstract: In the last years, nanostructured biomaterials have raised a great interest as platforms for delivery of drugs, genes, imaging agents and for tissue engineering applications. In particular, hydrogel nanoparticles (HNP) associate the distinctive features of hydrogels (high water uptake capacity, biocompatibility) with the advantages of being possible to tailor its physicochemical properties at nano-scale to increase solubility, immunocompatibility and cellular uptake. In order to be safe, HNP for biomedical applications, such as injectable or ophthalmic formulations, must be sterile. Literature is very scarce with respect to sterilization effects on nanostructured systems, and even more in what concerns HNP. This work aims to evaluate the effect and effectiveness of different sterilization methods on chitosan (CS) hydrogel nanoparticles. In addition to conventional methods (steam autoclave and gamma irradiation), a recent ozone-based method of sterilization was also tested. A model chitosan-tripolyphosphate (TPP) hydrogel nanoparticles (CS-HNP), with a broad spectrum of possible applications was produced and sterilized in the absence and in the presence of protective sugars (glucose and mannitol). Properties like size, zeta potential, absorbance, morphology, chemical structure and cytotoxicity were evaluated. It was found that the CS-HNP degrade by autoclaving and that sugars have no protective effect. Concerning gamma irradiation, the formation of agglomerates was observed, compromising the suspension stability. However, the nanoparticles resistance increases considerably in the presence of the sugars. Ozone sterilization did not lead to significant physical adverse effects, however, slight toxicity signs were observed, contrarily to gamma irradiation where no detectable changes on cells were found. Ozonation in the presence of sugars avoided cytotoxicity. Nevertheless, some chemical alterations were observed in the nanoparticles.Palavras-Chave: sterilization; oligosaccharides; hydrogels; nanoparticles; drug delivery; biological materials
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IPEN-DOC 25730
- PORTILHO, FILIPE L.
;- HELAL-NETO, EDWARD
;- CABEZAS, SANTIAGO S.
;- PINTO, SUYENE R.
;- SANTOS, SOFIA N. dos
;- POZZO, LORENA
; - SANCENON, FELIX
;- MARTINEZ-MANEZ, RAMON
;- SANTOS-OLIVEIRA, RALPH
. Magnetic core mesoporous silica nanoparticles doped with dacarbazine and labelled with 99mTc for early and differential detection of metastatic melanoma by single photon emission computed tomography. Artificial Cells, Nanomedicine, and Biotechnology, v. 46, S1, p. S1080–S1087, 2018. DOI: 10.1080/21691401.2018.1443941 Abstract: Cancer is responsible for more than 12% of all causes of death in the world, with an annual death rate of more than 7 million people. In this scenario melanoma is one of the most aggressive ones with serious limitation in early detection and therapy. In this direction we developed, characterized and tested in vivo a new drug delivery system based on magnetic core-mesoporous silica nanoparticle that has been doped with dacarbazine and labelled with technetium 99 m to be used as nano-imaging agent (nanoradiopharmaceutical) for early and differential diagnosis and melanoma by single photon emission computed tomography. The results demonstrated the ability of the magnetic core-mesoporous silica to be efficiently (>98%) doped with dacarbazine and also efficiently labelled with 99mTc (technetium 99 m) (>99%). The in vivo test, using inducted mice with melanoma, demonstrated the EPR effect of the magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled with technetium 99 metastable when injected intratumorally and the possibility to be used as systemic injection too. In both cases, magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled with technetium 99 metastable showed to be a reliable and efficient nano-imaging agent for melanoma.Palavras-Chave: melanomas; neoplasms; silica; nanoparticles; magnetic properties; magnetic cores; drug delivery; therapy; images; technetium 99
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IPEN-DOC 25727
- PORTILHO, FILIPE L.
;- PINTO, SUYENE R.
;- BARROS, ALINE O. da S. de
;- HELAL-NETO, EDWARD
;- SANTOS, SOFIA N. dos
; - BERNARDES, EMERSON S.
; - ILEM-OZDEMIR, DERYA
;- ASIKOGLU, MAKBULE
;- ALENCAR, LUCIANA M.R.
;- SANTOS, CLENILTON C. dos
;- RICCI-JUNIOR, EDUARDO
;- SANCENON, FELIX
;- MARTINEZ-MANEZ, RAMON
;- SANTOS-OLIVEIRA, RALPH
. In loco retention effect of magnetic core mesoporous silica nanoparticles doped with trastuzumab as intralesional nanodrug for breast cancer. Artificial Cells, Nanomedicine, and Biotechnology, v. 46, S3, p. S725-S733, 2018. DOI: 10.1080/21691401.2018.1508030 Abstract: Breast cancer is women’s most common type of cancer, with a global rate of over 522,000 deaths per year. One of the main problems related to breast cancer relies in the early detection, as the specialized treatment. In this direction was developed, characterized and tested in vivo a smart delivery system, based on radiolabelled magnetic core mesoporous silica doped with trastuzumab as intralesional nanodrug for breast cancer imaging and possible therapy. The results showed that nanoparticles had a size of 58.9 ± 8.1 nm, with specific surface area of 872 m2/g and pore volume of 0.85 cm3/g with a pore diameter of 3.15 nm. The magnetic core mesoporous silica was efficiently labelled with 99mTc (97.5% ±0.8) and doped >98%. The cytotoxicity assay, demonstrated they are safe to use. The data were corroborated with the IC50 result of: 829.6 mg ± 43.2. The biodistribution showed an uptake by the tumour of 7.5% (systemic via) and 97.37% (intralesional) with less than 3% of these nanoparticles absorbed by healthy tissues. In a period 6-h post-injection, no barrier delimited by the tumour was crossed, corroborating the use as intralesional nanodrug.Palavras-Chave: neoplasms; mammary glands; nanoparticles; silica; magnetic cores; equipment; drugs; drug delivery; atomic force microscopy; radiochemical analysis
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IPEN-DOC 23538
- PINO-RAMOS, VICTOR H.
;- RAMOS-BALLESTEROS, ALEJANDRO
;- LOPEZ-SAUCEDO, FELIPE
;- LOPEZ-BARRIGUETE, JESUS E.
;- VARCA, GUSTAVO H.C.
; - BUCIO, EMILIO
. Radiation grafting for the functionalization and development of smart polymeric materials. Topics in Current Chemistry, v. 374, n. 5, p. 1-28, 2016. DOI: 10.1007/s41061-016-0063-x Abstract: Gamma radiation has been shown particularly useful for the functionalization of surfaces with stimuli-responsive polymers. This method involves the formation of active sites (free radicals) onto the polymeric backbone as a result of the high-energy radiation exposition over the polymeric material. Thus, a microenvironment suitable for the reaction among monomer and/or polymer and the active sites is formed and then leading to propagation to form side-chain grafts. The modification of polymers using high-energy irradiation can be performed by the following methods: direct or simultaneous, pre-irradiation oxidative, and pre-irradiation. The most frequently used ones correspond to the pre-irradiation oxidative method as well as the direct one. Radiation-grafting has many advantages over other conventional methods because it does not require the use of catalyst nor additives to initiate the reaction and usually no changes on the mechanical properties with respect to the pristine polymeric matrix are observed. This chapter is focused on the synthesis of smart polymers and coatings obtained by the use of gamma radiation. In addition, the diverse applications of these materials in the biomedical area are also reported, with focus in drug delivery, sutures, and biosensors.Palavras-Chave: polymers; functions; functionals; drug delivery; sensors; graft polymers; gamma radiation
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IPEN-DOC 27585
- GONCALVES, KARINA de O.
;- VIEIRA, DANIEL P.
; - LEVY, DEBORA
;- BYDLOWSKI, SERGIO P.
;- COURROL, LILIA C.
. Uptake of silver, gold, and hybrids silver-iron, gold-iron and silver-gold aminolevulinic acid nanoparticles by MCF-7 breast cancer cells. Photodiagnosis and Photodynamic Therapy, v. 32, p. 1-10, 2020. DOI: 10.1016/j.pdpdt.2020.102080 Abstract: Background. Nanoparticles show promise for theranostic applications in cancer. The metal-based nanoparticles can be used both as photosensitizers and delivery vehicles. In bimetallic particles based on gold or silver and iron, a combination of the plasmonic features of the gold or silver components with the magnetic properties of the iron makes these hybrid nanomaterials suitable for both imaging and therapeutic applications. Herein, we discuss toxicity and cell internalization of metallic (silver and gold) and bimetallic (silver-iron, gold-iron, and silver-gold) aminolevulinic acid (ALA) nanoparticles. ALA can control the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), commonly used in photodynamic therapy. Methods. Nanoparticles were synthesized by photoreduction method and characterized by UV/Vis spectra, Zeta potential, FTIR, XRD, and transmission electron microscopy. The amount of singlet oxygen generation by a yellow LED, and ultrasound was studied for gold, gold-iron, and silver-gold nanoparticles. Cytotoxicity assays of MCF-7 in the presence of nanoparticles were performed, and PpIX fluorescence was quantified by high content screening (HCS). Results. Red fluorescence observed after 24 h of nanoparticles incubation on MCF-7 cells, indicated that the ALA in surface of nanoparticles was efficiently converted to PpIX. The best results for singlet oxygen generation with LED or ultrasound irradiation were obtained with ALA:AgAuNPs. Conclusions. The studied nanoparticles present the potential to deliver aminolevulinic acid to breast cancer cells efficiently, generate singlet oxygen, and convert ALA into PpIX inside the cells allowing photodiagnosis and therapies such as photodynamic and sonodynamic therapies.Palavras-Chave: gold; silver; nanoparticles; mammary glands; neoplasms; drug delivery; reduction; therapy; aminolevulinic acid
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IPEN-DOC 23142
- SCHMIDT, CHRISTIAN
;- YOKAICHYIA, FABIANO
;- DOGANGUZEL, NURDAN
;- FRANCO, MARGARETH K.K.D.
; - CAVALCANTI, LEIDE P.
;- BROWN, MARK A.
;- ALKSCHBIRS, MELISSA I.
;- ARAUJO, DANIELE R. de
;- KUMPUGDEE-VOLLRATH, MONT
;- STORSBERG, JOACHIM
. An abraded surface of doxorubicin-loaded surfactant-containing drug delivery systems effectively reduces the survival of carcinoma cells. v. 4, n. 3, 2016. DOI: 10.3390/biomedicines4030022 Abstract: An effective antitumor remedy is yet to be developed. All previous approaches for a targeted delivery of anticancer medicine have relied on trial and error. The goal of this study was to use structural insights gained from the study of delivery systems and malignant cells to provide for a systematic approach to the development of next-generation drugs. We used doxorubicin (Dox) liposomal formulations. We assayed for cytotoxicity via the electrical current exclusion method. Dialysis of the samples yielded information about their drug release profiles. Information about the surface of the delivery systems was obtained through synchrotron small-angle X-ray scattering (SAXS) measurements. SAXS measurements revealed that Dox-loading yielded an abraded surface of our Dox liposomal formulation containing soybean oil, which also correlated with an effective reduction of the survival of carcinoma cells. Furthermore, a dialysis assay revealed that a higher burst of Dox was released from soybean oil-containing preparations within the first five hours. We conclude from our results that an abraded surface of Dox-loaded drug delivery system increases their efficacy. The apparent match between surface geometry of drug delivery systems and target cells is suggested as a steppingstone for refined development of drug delivery systems. This is the first study to provide a systematic approach to developing next-generation drug carrier systems using structural insights to guide the development of next-generation drug delivery systems with increased efficacy and reduced side effects.Palavras-Chave: drug delivery; doxorubicin; neoplasms; therapy; synchrotron radiation; small angle scattering; x-ray diffraction; in vitro; carcinomas
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IPEN-DOC 28408
- HONEGGER, V.
;- SEO, E.S.M.
; - MIRANDA, L.F.
;- BARBOSA, I.T.F.
. Pseudoboehmite nanocarriers in cosmetic formulations. International Journal of Development Research, v. 11, n. 6, p. 47735-47738, 2021. DOI: 10.37118/ijdr.22018.06.2021 Abstract: The aim of this study is to contribute to the preparation and characterization of nanoemulsions for anti-aging cosmetic use. Palmarosa oil and Rosehip nanoemulsions were prepared with different active cosmetic ingredients such as mandelic acid and hyaluronic acid, in concentrations of 1%, 3% and 5% (wt%) of pseudoboehmite. After the nanoemulsions analysis, they were characterized in the following parameters: visual analysis, pH, density and optical microscopy. The results obtained show the possibility of using different compositions, the most suitable were: palmarosa oil nanoemulsion with 3 or 5wt% of mandellic acid/pseudoboehmite and palmarosa oil nanoemulsion with 1,3 or 5% of hyaluronic acid/pseudobohemite.Palavras-Chave: consumer products; hyaluronic acid; mandelic acid; emulsions; drug delivery
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A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.